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Cyclophilin A enhances vascular oxidative stress and development of angiotensin II-induced aortic aneurysms
Inflammation and oxidative stress are pathogenic mediators of many diseases, but therapeutic targets remain elusive. In the vasculature, abdominal aortic aneurysm (AAA) formation critically involves inflammaton and matrix degradation. Cyclophilin A (CyPA, encoded by Ppia) is highly expressed in vasc...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704983/ https://www.ncbi.nlm.nih.gov/pubmed/19430489 http://dx.doi.org/10.1038/nm.1958 |