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Cyclophilin A enhances vascular oxidative stress and development of angiotensin II-induced aortic aneurysms

Inflammation and oxidative stress are pathogenic mediators of many diseases, but therapeutic targets remain elusive. In the vasculature, abdominal aortic aneurysm (AAA) formation critically involves inflammaton and matrix degradation. Cyclophilin A (CyPA, encoded by Ppia) is highly expressed in vasc...

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Detalles Bibliográficos
Autores principales:	Satoh, Kimio, Nigro, Patrizia, Matoba, Tetsuya, O'Dell, Michael R., Cui, Zhaoqiang, Shi, Xi, Mohan, Amy, Yan, Chen, Abe, Jun-ichi, Illig, Karl A., Berk, Bradford C.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704983/ https://www.ncbi.nlm.nih.gov/pubmed/19430489 http://dx.doi.org/10.1038/nm.1958

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