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DNA Repair and DNA Triplet Repeat Expansion: The Impact of Abasic Lesions on Triplet Repeat DNA Energetics

[Image: see text] Enhanced levels of DNA triplet expansion are observed when base excision repair (BER) of oxidative DNA base damage (e.g., 8-oxo-dG) occurs at or near CAG repeat sequences. This observation suggests an interplay between processing mechanisms required for DNA repair and expansion pat...

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Detalles Bibliográficos
Autores principales: Völker, Jens, Plum, G. Eric, Klump, Horst H., Breslauer, Kenneth J.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705181/
https://www.ncbi.nlm.nih.gov/pubmed/19566100
http://dx.doi.org/10.1021/ja902161e