Structural Basis for Functional Tetramerization of Lentiviral Integrase

Experimental evidence suggests that a tetramer of integrase (IN) is the protagonist of the concerted strand transfer reaction, whereby both ends of retroviral DNA are inserted into a host cell chromosome. Herein we present two crystal structures containing the N-terminal and the catalytic core domai...

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Detalles Bibliográficos
Autores principales: Hare, Stephen, Di Nunzio, Francesca, Labeja, Alfred, Wang, Jimin, Engelman, Alan, Cherepanov, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705190/
https://www.ncbi.nlm.nih.gov/pubmed/19609359
http://dx.doi.org/10.1371/journal.ppat.1000515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705190/
https://www.ncbi.nlm.nih.gov/pubmed/19609359
http://dx.doi.org/10.1371/journal.ppat.1000515

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