Proliferation Defects and Genome Instability in Cells Lacking Cul4A

The Cul4A gene, which encodes a core component of a cullin-based E3 ubiquitin ligase complex, is over-expressed in breast and hepatocellular cancers. In breast cancers, over-expression of Cul4A strongly correlates with poor prognosis. Also, Cul4A is required for early embryonic development. Early le...

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Detalles Bibliográficos
Autores principales: Kopanja, Dragana, Stoyanova, Tanya, Okur, Nazir M., Huang, Erin, Bagchi, Srilata, Raychaudhuri, Pradip
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705479/
https://www.ncbi.nlm.nih.gov/pubmed/19430492
http://dx.doi.org/10.1038/onc.2009.86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705479/
https://www.ncbi.nlm.nih.gov/pubmed/19430492
http://dx.doi.org/10.1038/onc.2009.86

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