A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs

PURPOSE: To develop a new minimal-stress model for intranasal administration in freely moving rats and to evaluate in this model the brain distribution of acetaminophen following intranasal versus intravenous administration. METHODS: Male Wistar rats received one intranasal cannula, an intra-cerebra...

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Detalles Bibliográficos
Autores principales: Stevens, Jasper, Suidgeest, Ernst, van der Graaf, Piet Hein, Danhof, Meindert, de Lange, Elizabeth C. M.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705718/
https://www.ncbi.nlm.nih.gov/pubmed/19452129
http://dx.doi.org/10.1007/s11095-009-9907-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705718/
https://www.ncbi.nlm.nih.gov/pubmed/19452129
http://dx.doi.org/10.1007/s11095-009-9907-1

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