BRaf(V600E) cooperates with Pten silencing to elicit metastatic melanoma

Mutational activation of BRAF is the earliest and most common genetic alteration in human melanoma. Hence, to build a model of human melanoma, we generated mice with conditional melanocyte-specific expression of BRaf(V600E). Upon induction of BRaf(V600E) expression, mice developed benign melanocytic...

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Detalles Bibliográficos
Autores principales: Dankort, David, Curley, David P., Cartlidge, Robert A., Nelson, Betsy, Karnezis, Anthony N., Damsky, William E., You, Mingjian J., DePinho, Ronald A., McMahon, Martin, Bosenberg, Marcus
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705918/
https://www.ncbi.nlm.nih.gov/pubmed/19282848
http://dx.doi.org/10.1038/ng.356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705918/
https://www.ncbi.nlm.nih.gov/pubmed/19282848
http://dx.doi.org/10.1038/ng.356

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