Positive Epistasis Drives the Acquisition of Multidrug Resistance

The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact—epistasis. Information on the level of epistasis betw...

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Detalles Bibliográficos
Autores principales: Trindade, Sandra, Sousa, Ana, Xavier, Karina Bivar, Dionisio, Francisco, Ferreira, Miguel Godinho, Gordo, Isabel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706973/
https://www.ncbi.nlm.nih.gov/pubmed/19629166
http://dx.doi.org/10.1371/journal.pgen.1000578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706973/
https://www.ncbi.nlm.nih.gov/pubmed/19629166
http://dx.doi.org/10.1371/journal.pgen.1000578

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