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Positive Epistasis Drives the Acquisition of Multidrug Resistance
The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact—epistasis. Information on the level of epistasis betw...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706973/ https://www.ncbi.nlm.nih.gov/pubmed/19629166 http://dx.doi.org/10.1371/journal.pgen.1000578 |