Bacterial Thymidine Kinase as a Non-Invasive Imaging Reporter for Mycobacterium tuberculosis in Live Animals

BACKGROUND: Bacteria can be selectively imaged in experimentally-infected animals using exogenously administered 1-(2′deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-[(125)I]-iodouracil ([(125)I]-FIAU), a nucleoside analog substrate for bacterial thymidine kinase (TK). Our goal was to use this reporter and...

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Detalles Bibliográficos
Autores principales: Davis, Stephanie L., Be, Nicholas A., Lamichhane, Gyanu, Nimmagadda, Sridhar, Pomper, Martin G., Bishai, William R., Jain, Sanjay K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706987/
https://www.ncbi.nlm.nih.gov/pubmed/19606217
http://dx.doi.org/10.1371/journal.pone.0006297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706987/
https://www.ncbi.nlm.nih.gov/pubmed/19606217
http://dx.doi.org/10.1371/journal.pone.0006297

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