Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

The polyproteins of coronaviruses are cleaved by viral proteases into at least 15 nonstructural proteins (Nsps). Consisting of five domains, Nsp3 is the largest of these (180–210 kDa). Among these domains, the so-called X-domain is believed to act as ADP-ribose-1″-phosphate phosphatase or to bind po...

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Detalles Bibliográficos
Autores principales: Piotrowski, Yvonne, Hansen, Guido, Boomaars-van der Zanden, A Linda, Snijder, Eric J, Gorbalenya, Alexander E, Hilgenfeld, Rolf
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2009
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708038/
https://www.ncbi.nlm.nih.gov/pubmed/19177346
http://dx.doi.org/10.1002/pro.15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708038/
https://www.ncbi.nlm.nih.gov/pubmed/19177346
http://dx.doi.org/10.1002/pro.15

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