Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HIP

Hedgehog (Hh) morphogens play fundamental roles in development whilst dysregulation of Hh signaling leads to disease. Multiple cell surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the hedgehog-interacting protein (HIP) is a highly conserved, vertebrate-sp...

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Detalles Bibliográficos
Autores principales: Bishop, Benjamin, Aricescu, A. Radu, Harlos, Karl, O’Callaghan, Chris A., Jones, E. Yvonne, Siebold, Christian
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709225/
https://www.ncbi.nlm.nih.gov/pubmed/19561611
http://dx.doi.org/10.1038/nsmb.1607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709225/
https://www.ncbi.nlm.nih.gov/pubmed/19561611
http://dx.doi.org/10.1038/nsmb.1607

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