The Utility of Oligopeptidase in Brain-Targeting Delivery of an Enkephalin Analogue by Prodrug Design

In a brain-targeting prodrug approach for a metabolically stable enkephalin analogue DADLE, specific enzymes are utilized for in vivo prodrug activation. Prolyl oligopeptidase (POP) may be especially useful in this regard. In vitro metabolic stability of the putative metabolites of prodrugs having v...

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Detalles Bibliográficos
Autores principales: Prokai-Tatrai, K, Kim, H.-S, Prokai, L
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709471/
https://www.ncbi.nlm.nih.gov/pubmed/19662149
http://dx.doi.org/10.2174/1874104500802010097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709471/
https://www.ncbi.nlm.nih.gov/pubmed/19662149
http://dx.doi.org/10.2174/1874104500802010097

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