Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

Endonucleolytic cleavage of the coding region determinant (CRD) of c-myc mRNA appears to play a critical role in regulating c-myc mRNA turnover. Using (32)P-labeled c-myc CRD RNA as substrate, we have purified and identified two endoribonucleases from rat liver polysomes that are capable of cleaving...

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Detalles Bibliográficos
Autores principales: Barnes, Tavish, Kim, Wan-Cheol, Mantha, Anil K., Kim, Sang-Eun, Izumi, Tadahide, Mitra, Sankar, Lee, Chow H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acids Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709568/
https://www.ncbi.nlm.nih.gov/pubmed/19401441
http://dx.doi.org/10.1093/nar/gkp275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709568/
https://www.ncbi.nlm.nih.gov/pubmed/19401441
http://dx.doi.org/10.1093/nar/gkp275

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