Experimentally based contact energies decode interactions responsible for protein–DNA affinity and the role of molecular waters at the binding interface

A major obstacle towards understanding the molecular basis of transcriptional regulation is the lack of a recognition code for protein–DNA interactions. Using high-quality crystal structures and binding data on the promiscuous family of C(2)H(2) zinc fingers (ZF), we decode 10 fundamental specific i...

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Detalles Bibliográficos
Autores principales: Temiz, N. Alpay, Camacho, Carlos J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709573/
https://www.ncbi.nlm.nih.gov/pubmed/19429892
http://dx.doi.org/10.1093/nar/gkp289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709573/
https://www.ncbi.nlm.nih.gov/pubmed/19429892
http://dx.doi.org/10.1093/nar/gkp289

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