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Experimentally based contact energies decode interactions responsible for protein–DNA affinity and the role of molecular waters at the binding interface
A major obstacle towards understanding the molecular basis of transcriptional regulation is the lack of a recognition code for protein–DNA interactions. Using high-quality crystal structures and binding data on the promiscuous family of C(2)H(2) zinc fingers (ZF), we decode 10 fundamental specific i...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709573/ https://www.ncbi.nlm.nih.gov/pubmed/19429892 http://dx.doi.org/10.1093/nar/gkp289 |