Improved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the U(L)13 protein kinase and specific components of the VP16 transcriptional complex

BACKGROUND: Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short-term expression. These results raise the paradox that recombinant gene express...

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Detalles Bibliográficos
Autores principales: Liu, Meng, Wang, Xiaodan, Geller, Alfred I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709626/
https://www.ncbi.nlm.nih.gov/pubmed/19531264
http://dx.doi.org/10.1186/1471-2199-10-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709626/
https://www.ncbi.nlm.nih.gov/pubmed/19531264
http://dx.doi.org/10.1186/1471-2199-10-58

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