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Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug
BACKGROUND: N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N''-4-pyridyl guanidine) (CHS 828) is the first candidate drug from a novel group of anti-tumour agents – the pyridyl cyanoguanidines, shown to be potent compounds interfering with cellular metabolism (inhibition of nicotinamide phosph...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709656/ https://www.ncbi.nlm.nih.gov/pubmed/19563661 http://dx.doi.org/10.1186/1756-0500-2-114 |