Purinergic P2X(7) receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

AIMS/HYPOTHESIS: In obesity, beta cells activate compensatory mechanisms to adapt to the higher insulin demand. Interleukin-1 receptor antagonist (IL-1Ra) prevents obesity-induced hyperglycaemia and is a potent target for the treatment of diabetes, but the mechanisms of its secretion and regulation...

Descripción completa

Detalles Bibliográficos
Autores principales: Glas, R., Sauter, N. S., Schulthess, F. T., Shu, L., Oberholzer, J., Maedler, K.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709906/
https://www.ncbi.nlm.nih.gov/pubmed/19396427
http://dx.doi.org/10.1007/s00125-009-1349-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709906/
https://www.ncbi.nlm.nih.gov/pubmed/19396427
http://dx.doi.org/10.1007/s00125-009-1349-0

Ejemplares similares