Coupled Stochastic Spatial and Non-Spatial Simulations of ErbB1 Signaling Pathways Demonstrate the Importance of Spatial Organization in Signal Transduction

BACKGROUND: The ErbB family of receptors activates intracellular signaling pathways that control cellular proliferation, growth, differentiation and apoptosis. Given these central roles, it is not surprising that overexpression of the ErbB receptors is often associated with carcinogenesis. Therefore...

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Detalles Bibliográficos
Autores principales: Costa, Michelle N., Radhakrishnan, Krishnan, Wilson, Bridget S., Vlachos, Dionisios G., Edwards, Jeremy S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710010/
https://www.ncbi.nlm.nih.gov/pubmed/19626123
http://dx.doi.org/10.1371/journal.pone.0006316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710010/
https://www.ncbi.nlm.nih.gov/pubmed/19626123
http://dx.doi.org/10.1371/journal.pone.0006316

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