Development of Peptidomimetics Targeting IAPs

Inhibitor of apoptosis proteins (IAPs) such as XIAP subvert apoptosis by binding and inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac abolishes the XIAP–caspase 9 interaction, it is a proapoptotic event of great therapeutic interest. An assay for pocket binding...

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Detalles Bibliográficos
Autores principales: Sharma, Sushil K., Straub, Christopher, Zawel, Leigh
Formato: Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710984/
https://www.ncbi.nlm.nih.gov/pubmed/19617919
http://dx.doi.org/10.1007/s10989-005-9003-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710984/
https://www.ncbi.nlm.nih.gov/pubmed/19617919
http://dx.doi.org/10.1007/s10989-005-9003-2

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