Utility of Pretreatment Bilirubin Level and UGT1A1 Polymorphisms in Multivariate Predictive Models of Neutropenia Associated with Irinotecan Treatment in Previously Untreated Patients with Colorectal Cancer

PURPOSE: Statistical models for predicting hematologic toxicity were evaluated based on UGT1A1 polymorphisms and baseline serum bilirubin. METHODS: Blood DNA samples were collected from 113 patients with untreated metastatic colorectal cancer receiving irinotecan (FOLFIRI, n = 36; mIFL, n = 41; Cape...

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Detalles Bibliográficos
Autores principales: Parodi, Luis, Pickering, Eve, Cisar, Laura A, Lee, Doug, Soufi-Mahjoubi, Raoudha
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710994/
https://www.ncbi.nlm.nih.gov/pubmed/19639031
http://dx.doi.org/10.1111/j.1753-5174.2008.00014.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710994/
https://www.ncbi.nlm.nih.gov/pubmed/19639031
http://dx.doi.org/10.1111/j.1753-5174.2008.00014.x

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