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Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73

BACKGROUND: The p53 tumor suppressor and its related protein, p73, share a homologous DNA binding domain, and mouse genetics studies have suggested that they have overlapping as well as distinct biological functions. Both p53 and p73 are activated by genotoxic stress to regulate an array of cellular...

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Detalles Bibliográficos
Autores principales: Huang, Vera, Lu, Xin, Jiang, Yong, Wang, Jean YJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711048/
https://www.ncbi.nlm.nih.gov/pubmed/19558638
http://dx.doi.org/10.1186/1741-7007-7-35