Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

Promoting the degradation of Hsp90 client proteins by inhibiting Hsp90, an important protein chaperone, has been shown to be a promising new anticancer strategy. In this study, we show that an oxazoline analogue of apratoxin A (oz-apraA), a cyclodepsipeptide isolated from a marine cyanobacterium, pr...

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Detalles Bibliográficos
Autores principales: Shen, Shensi, Zhang, Pengtao, Lovchik, Martin A., Li, Ying, Tang, Liuya, Chen, Zhimin, Zeng, Rong, Ma, Dawei, Yuan, Junying, Yu, Qiang
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711573/
https://www.ncbi.nlm.nih.gov/pubmed/19433452
http://dx.doi.org/10.1083/jcb.200810183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711573/
https://www.ncbi.nlm.nih.gov/pubmed/19433452
http://dx.doi.org/10.1083/jcb.200810183

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