Conserved cryptic recombination signals in Vκ gene segments are cleaved in small pre-B cells

BACKGROUND: The cleavage of recombination signals (RS) at the boundaries of immunoglobulin V, D, and J gene segments initiates the somatic generation of the antigen receptor genes expressed by B lymphocytes. RS contain a conserved heptamer and nonamer motif separated by non-conserved spacers of 12 o...

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Detalles Bibliográficos
Autores principales: Lieberman, Anne E, Kuraoka, Masayuki, Davila, Marco, Kelsoe, Garnett, Cowell, Lindsay G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711918/
https://www.ncbi.nlm.nih.gov/pubmed/19555491
http://dx.doi.org/10.1186/1471-2172-10-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711918/
https://www.ncbi.nlm.nih.gov/pubmed/19555491
http://dx.doi.org/10.1186/1471-2172-10-37

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