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Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases

Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-κB). While these character...

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Detalles Bibliográficos
Autores principales: Suzuki, Jun-ichi, Isobe, Mitsuaki, Morishita, Ryuichi, Nagai, Ryozo
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712737/
https://www.ncbi.nlm.nih.gov/pubmed/19636434
http://dx.doi.org/10.1155/2009/494928
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author Suzuki, Jun-ichi
Isobe, Mitsuaki
Morishita, Ryuichi
Nagai, Ryozo
author_facet Suzuki, Jun-ichi
Isobe, Mitsuaki
Morishita, Ryuichi
Nagai, Ryozo
author_sort Suzuki, Jun-ichi
collection PubMed
description Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-κB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.
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spelling pubmed-27127372009-07-27 Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases Suzuki, Jun-ichi Isobe, Mitsuaki Morishita, Ryuichi Nagai, Ryozo Mediators Inflamm Review Article Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-κB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways. Hindawi Publishing Corporation 2009 2009-07-19 /pmc/articles/PMC2712737/ /pubmed/19636434 http://dx.doi.org/10.1155/2009/494928 Text en Copyright © 2009 Jun-ichi Suzuki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Suzuki, Jun-ichi
Isobe, Mitsuaki
Morishita, Ryuichi
Nagai, Ryozo
Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
title Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
title_full Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
title_fullStr Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
title_full_unstemmed Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
title_short Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
title_sort tea polyphenols regulate key mediators on inflammatory cardiovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712737/
https://www.ncbi.nlm.nih.gov/pubmed/19636434
http://dx.doi.org/10.1155/2009/494928
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