Cargando…

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

OBJECTIVE: The activation of AMP-activated protein kinase (AMPK) has been reported to improve endothelial function. However, the targets of AMPK in endothelial cells remain poorly defined. The aim of this study was to test whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a ke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Shuangxi, Xu, Jian, Song, Ping, Viollet, Benoit, Zou, Ming-Hui
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712774/ https://www.ncbi.nlm.nih.gov/pubmed/19528375 http://dx.doi.org/10.2337/db09-0267

Ejemplares similares

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Non-Covalent Interaction between Polyubiquitin and GTP Cyclohydrolase 1 Dictates Its Degradation
por: Zhao, Yu, et al.
Publicado: (2012)

Activation of the AMP-Activated Protein Kinase by Eicosapentaenoic Acid (EPA, 20:5 n-3) Improves Endothelial Function In Vivo
por: Wu, Yong, et al.
Publicado: (2012)

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
por: Kümpornsin, Krittikorn, et al.
Publicado: (2014)

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
por: Ebenhoch, Rebecca, et al.
Publicado: (2020)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolo E., et al.
Publicado: (2015)

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women
por: Wu, Shaohong, et al.
Publicado: (2020)

AMP-Activated Protein Kinase Signalling
por: Neumann, Dietbert, et al.
Publicado: (2019)

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
por: Wu, Hsiang-En, et al.
Publicado: (2016)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
por: Kraft, Vanessa A. N., et al.
Publicado: (2019)

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
por: Xie, Zhonglin, et al.
Publicado: (2008)

Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo
por: Yin, Ya-Ling, et al.
Publicado: (2022)

GTP Cyclohydrolase I and Tyrosine Hydroxylase Gene Mutations in Familial and Sporadic Dopa-Responsive Dystonia Patients
por: Cai, Chunyou, et al.
Publicado: (2013)

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target
por: Schüssler, Sonja, et al.
Publicado: (2019)

Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor
por: Liu, Shiwei, et al.
Publicado: (2023)

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches
por: Hussein, D, et al.
Publicado: (2015)

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans
por: Kim, Hyungsuk, et al.
Publicado: (2007)

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
por: Liu, Yanan, et al.
Publicado: (2017)

Identification and Functional Analysis of GTP Cyclohydrolase II in Candida glabrata in Response to Nitrosative Stress
por: Nasuno, Ryo, et al.
Publicado: (2022)

Serotonergic system in vivo with [(11)C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients
por: Timmers, Elze R., et al.
Publicado: (2022)

A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast
por: Anam, Khairul, et al.
Publicado: (2020)

GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus
por: Wolkow, Pawel P., et al.
Publicado: (2014)

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
por: Domise, Manon, et al.
Publicado: (2016)

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth
por: Chen, Liye, et al.
Publicado: (2016)

Overexpression of GTP Cyclohydrolase 1 Feedback Regulatory Protein Is Protective in a Murine Model of Septic Shock
por: Starr, Anna, et al.
Publicado: (2014)

Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo
por: Li, Peng, et al.
Publicado: (2016)

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo
por: Dong, Yunzhou, et al.
Publicado: (2010)

Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis
por: Mustafa, Aya M., et al.
Publicado: (2021)

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
por: Lazarev, Mark, et al.
Publicado: (2008)

Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status
por: Asensio Lopez, Maria del Carmen, et al.
Publicado: (2020)

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth
por: Chuaiphichai, Surawee, et al.
Publicado: (2021)

AMP Activated Protein Kinase Is Indispensable for Myocardial Adaptation to Caloric Restriction in Mice
por: Chen, Kai, et al.
Publicado: (2013)

Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase
por: Fisher, Gemma, et al.
Publicado: (2023)

Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain
por: Nasser, Arafat, et al.
Publicado: (2013)

GTP-Cyclohydrolase I deficiency presenting as malignant hyperphenylalaninemia, recurrent hyperthermia and progressive neurological dysfunction in a South Asian child – a case report
por: Dayasiri, Kavinda Chandimal, et al.
Publicado: (2019)

Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana
por: Osei, Musah, et al.
Publicado: (2018)

Author Correction: Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status
por: del Carmen Asensio Lopez, Maria, et al.
Publicado: (2020)

Redox Regulation of the AMP-Activated Protein Kinase
por: Han, Yingying, et al.
Publicado: (2010)

AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice
por: Hulo, Sébastien, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_3np717kbfogmb2vbdj1aumo5mk