Kir6.2 Variant E23K Increases ATP-Sensitive K(+) Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance

OBJECTIVE: The E23K variant in the Kir6.2 subunit of the ATP-sensitive K(+) channel (K(ATP) channel) is associated with increased risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms responsible. To avoid confounding effects of hyperglycemia, insu...

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Detalles Bibliográficos
Autores principales: Villareal, Dennis T., Koster, Joseph C., Robertson, Heather, Akrouh, Alejandro, Miyake, Kazuaki, Bell, Graeme I., Patterson, Bruce W., Nichols, Colin G., Polonsky, Kenneth S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712777/
https://www.ncbi.nlm.nih.gov/pubmed/19491206
http://dx.doi.org/10.2337/db09-0025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712777/
https://www.ncbi.nlm.nih.gov/pubmed/19491206
http://dx.doi.org/10.2337/db09-0025

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