Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

OBJECTIVE: Proinflammatory cytokines are cytotoxic to β-cells and have been implicated in the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic mitochondrial apoptotic pathway in cytokine-induced β-cell death is unclear. Here, cytokine activation of the intrins...

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Detalles Bibliográficos
Autores principales: Grunnet, Lars G., Aikin, Reid, Tonnesen, Morten F., Paraskevas, Steven, Blaabjerg, Lykke, Størling, Joachim, Rosenberg, Lawrence, Billestrup, Nils, Maysinger, Dusica, Mandrup-Poulsen, Thomas
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712790/
https://www.ncbi.nlm.nih.gov/pubmed/19470609
http://dx.doi.org/10.2337/db08-0178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712790/
https://www.ncbi.nlm.nih.gov/pubmed/19470609
http://dx.doi.org/10.2337/db08-0178

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