Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

OBJECTIVE: Insufficient insulin secretion is a hallmark of type 2 diabetes, and exposure of β-cells to elevated lipid levels (lipotoxicity) contributes to secretory dysfunction. Functional ablation of protein kinase C ε (PKCε) has been shown to improve glucose homeostasis in models of type 2 diabete...

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Detalles Bibliográficos
Autores principales: Cantley, James, Burchfield, James G., Pearson, Gemma L., Schmitz-Peiffer, Carsten, Leitges, Michael, Biden, Trevor J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712791/
https://www.ncbi.nlm.nih.gov/pubmed/19401415
http://dx.doi.org/10.2337/db09-0132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712791/
https://www.ncbi.nlm.nih.gov/pubmed/19401415
http://dx.doi.org/10.2337/db09-0132

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