Cargando…

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

OBJECTIVE: Insufficient insulin secretion is a hallmark of type 2 diabetes, and exposure of β-cells to elevated lipid levels (lipotoxicity) contributes to secretory dysfunction. Functional ablation of protein kinase C ε (PKCε) has been shown to improve glucose homeostasis in models of type 2 diabete...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cantley, James, Burchfield, James G., Pearson, Gemma L., Schmitz-Peiffer, Carsten, Leitges, Michael, Biden, Trevor J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712791/ https://www.ncbi.nlm.nih.gov/pubmed/19401415 http://dx.doi.org/10.2337/db09-0132

Ejemplares similares

PKCδ Blues for the β-Cell
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2010)

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2008)

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity
por: Wu, Lindsay E., et al.
Publicado: (2014)

Sweet and Sour β-Cells: ROS and Hif1α Induce Warburg-Like Lactate Production During Type 2 Diabetes
por: Cantley, James, et al.
Publicado: (2013)

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent
por: Iismaa, Siiri E., et al.
Publicado: (2013)

Protein Kinase Cε Modulates Insulin Receptor Localization and Trafficking in Mouse Embryonic Fibroblasts
por: Pedersen, David J., et al.
Publicado: (2013)

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass
por: Cantley, James, et al.
Publicado: (2018)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

Anarchy in the UPR: a Ca(2+)-insensitive PKC inhibits SERCA activity to promote ER stress
por: Schmitz-Peiffer, Carsten
Publicado: (2018)

Kinetics of PKCε Activating and Inhibiting Llama Single Chain Antibodies and Their Effect on PKCε Translocation in HeLa Cells
por: Summanen, Milla, et al.
Publicado: (2012)

Impact of PKCε downregulation on autophagy in glioblastoma cells
por: Toton, Ewa, et al.
Publicado: (2018)

Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer
por: Hafeez, Bilal Bin, et al.
Publicado: (2016)

PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer’s Disease Hippocampus
por: Millien, Guetchyn, et al.
Publicado: (2022)

Ethanol-Induced Changes in PKCε: From Cell to Behavior
por: Pakri Mohamed, Rashidi M., et al.
Publicado: (2018)

Mechanism of PKCε regulation of cardiac GIRK channel gating
por: Gada, Kirin D., et al.
Publicado: (2022)

Exploring the prognostic significance of PKCε variants in cervical cancer
por: Zafar, Sameen, et al.
Publicado: (2023)

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
por: Cantley, James, et al.
Publicado: (2015)

Glutamate is an essential mediator in glutamine‐amplified insulin secretion
por: Han, Guirong, et al.
Publicado: (2021)

Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
por: Cantley, James, et al.
Publicado: (2019)

PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription
por: Christina, Lutz-Nicoladoni, et al.
Publicado: (2013)

PKCε Phosphorylates and Mediates the Cell Membrane Localization of RhoA
por: Su, Tizhi, et al.
Publicado: (2013)

Mitotic catenation is monitored and resolved by a PKCε-regulated pathway
por: Brownlow, Nicola, et al.
Publicado: (2014)

IKKε inhibits PKC to promote Fascin-dependent actin bundling
por: Otani, Tetsuhisa, et al.
Publicado: (2016)

A cancer-associated, genome protective programme engaging PKCε
por: Parker, Peter J., et al.
Publicado: (2020)

Correction: Exploring the prognostic significance of PKCε variants in cervical cancer
por: Zafar, Sameen, et al.
Publicado: (2023)

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination
por: Garcia, Neus, et al.
Publicado: (2019)

Expression pattern of Protein Kinase C ϵ during mouse embryogenesis
por: Carracedo, Sergio, et al.
Publicado: (2013)

Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway
por: Metz, Matthäus, et al.
Publicado: (2023)

Targeting Ceramide Synthesis to Reverse Insulin Resistance
por: Schmitz-Peiffer, Carsten
Publicado: (2010)

Thienoquinolines as Novel Disruptors of the PKCε/RACK2 Protein–Protein Interaction
por: Rechfeld, Florian, et al.
Publicado: (2014)

PKCε and allopregnanolone: functional cross-talk at the GABA(A) receptor level
por: Puia, Giulia, et al.
Publicado: (2015)

COX-2 MEDIATES PRO-TUMORIGENIC EFFECTS OF PKCε IN PROSTATE CANCER
por: Garg, Rachana, et al.
Publicado: (2018)

PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines
por: Jendzjowsky, Nicholas G., et al.
Publicado: (2020)

Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion
por: Inouye, Karen E., et al.
Publicado: (2023)

Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue
por: Son, Yeonho, et al.
Publicado: (2020)

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis
por: Sajan, Mini P, et al.
Publicado: (2014)

RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women
por: Kilicarslan, Murat, et al.
Publicado: (2020)

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies()
por: Blanchard, Anne A., et al.
Publicado: (2019)

Diverse dynamics features of novel protein kinase C (PKC) isozymes determine the selectivity of a fluorinated balanol analogue for PKCε
por: Hardianto, Ari, et al.
Publicado: (2019)

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion
por: Prentice, Kacey J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_to031k3m1ugmrbncmb5rhq69he