Cargando…

Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop

OBJECTIVE: The gluco-incretin hormones glucagon-like peptide (GLP)-1 and gastric inhibitory peptide (GIP) protect β-cells against cytokine-induced apoptosis. Their action is initiated by binding to specific receptors that activate the cAMP signaling pathway, but the downstream events are not fully e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cornu, Marion, Yang, Jiang-Yan, Jaccard, Evrim, Poussin, Carine, Widmann, Christian, Thorens, Bernard
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712796/ https://www.ncbi.nlm.nih.gov/pubmed/19401425 http://dx.doi.org/10.2337/db09-0063

Ejemplares similares

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
por: Klöting, Nora, et al.
Publicado: (2008)

Maintenance of Stemness in Oxaliplatin-Resistant Hepatocellular Carcinoma Is Associated with Increased Autocrine of IGF1
por: Bu, Yang, et al.
Publicado: (2014)

An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
por: Zheng, Xianan, et al.
Publicado: (2019)

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis
por: De Giovanni, Carla, et al.
Publicado: (2019)

E-Peptides Control Bioavailability of IGF-1
por: Hede, Marianne Smedegaard, et al.
Publicado: (2012)

BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma
por: Loganathan, Sudan N., et al.
Publicado: (2016)

The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives
por: Scalia, Pierluigi, et al.
Publicado: (2020)

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells
por: Arous, Caroline, et al.
Publicado: (2021)

Inhibition of IGF-1 receptor kinase blocks the differentiation into cardiomyocyte-like cells of BMSCs induced by IGF-1
por: Gong, Haibin, et al.
Publicado: (2017)

IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
por: Rojas, Andres, et al.
Publicado: (2011)

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis
por: Ferrón, S. R., et al.
Publicado: (2015)

Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
por: Sandovici, Ionel, et al.
Publicado: (2021)

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
por: Chang, Hua-Pin, et al.
Publicado: (2018)

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells
por: Tominaga, K, et al.
Publicado: (2017)

Neuronal regulation of glucagon secretion and gluconeogenesis
por: Thorens, Bernard
Publicado: (2022)

Novel Mechanisms for IGF-I Regulation by Glucagon in Carp Hepatocytes: Up-Regulation of HNF1α and CREB Expression via Signaling Crosstalk for IGF-I Gene Transcription
por: Bai, Jin, et al.
Publicado: (2019)

Stability of glucagon-like peptide 1 and glucagon in human plasma
por: Wewer Albrechtsen, Nicolai J, et al.
Publicado: (2015)

Computational Peptide Design Cotargeting Glucagon and Glucagon-like Peptide-1 Receptors
por: Vishnoi, Shubham, et al.
Publicado: (2023)

Glucagon-Like Peptide-1 and Diabetes
por: Monami, Matteo
Publicado: (2011)

Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer
por: Sipos, Ferenc, et al.
Publicado: (2017)

IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa
por: Cannarella, Rossella, et al.
Publicado: (2020)

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators
por: Suh, Hyeon-Sook, et al.
Publicado: (2013)

Glucagon-like peptide 1 (GLP-1)
por: Müller, T.D., et al.
Publicado: (2019)

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor
por: Underwood, Christina Rye, et al.
Publicado: (2010)

Glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes
por: Lee, Seungah, et al.
Publicado: (2017)

Insulin growth factor 1 like receptor (IGF-1R)
por: Iyer, Gopal, et al.
Publicado: (2016)

Does Reduced IGF-1R Signaling in Igf1r (+/−) Mice Alter Aging?
por: Bokov, Alex F., et al.
Publicado: (2011)

The IGF1 P2 promoter is an epigenetic QTL for circulating IGF1 and human growth
por: Ouni, Meriem, et al.
Publicado: (2015)

Various phenotypes of short stature with heterozygous IGF-1 receptor (IGF1R) mutations
por: Kawashima-Sonoyama, Yuki, et al.
Publicado: (2022)

Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
por: Vella, A., et al.
Publicado: (2008)

IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop
por: Ren, Hongxia, et al.
Publicado: (2008)

Role of IGF-1R in ameliorating apoptosis of GNE deficient cells
por: Singh, Reema, et al.
Publicado: (2018)

IGF‑1 inhibits palmitic acid‑induced mitochondrial apoptosis in macrophages
por: Tang, Wanying, et al.
Publicado: (2023)

Possible role of the Ec peptide of IGF-1Ec in cartilage repair
por: Armakolas, Nikolaos, et al.
Publicado: (2016)

Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation
por: Zhou, Chan, et al.
Publicado: (2021)

A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor
por: Zhang, Fa, et al.
Publicado: (2021)

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
por: Moreau, Francois, et al.
Publicado: (2022)

Glucagon-like peptide-1 and glucagon-like peptide-2 regulation during human liver regeneration
por: Ammann, Markus, et al.
Publicado: (2023)

Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis
por: Mahran, Yasmen F., et al.
Publicado: (2015)

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II
por: Alvino, Clair L., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_l6e8207ope98ban3b4nrm3i3qg