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Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

TRPC5 is a calcium (Ca(2+))-permeable nonselective cation channel expressed in several brain regions, including the hippocampus, cerebellum, and amygdala. Although TRPC5 is activated by receptors coupled to phospholipase C, the precise signaling pathway and modulatory signals remain poorly defined....

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Detalles Bibliográficos
Autores principales: Blair, Nathaniel T., Kaczmarek, J. Stefan, Clapham, David E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712973/
https://www.ncbi.nlm.nih.gov/pubmed/19398778
http://dx.doi.org/10.1085/jgp.200810153