Structure of C3b-factor H and implications for host protection by complement regulators

Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insights into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target C3b. FH interacts with multi...

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Detalles Bibliográficos
Autores principales: Wu, Jin, Wu, You-Qiang, Ricklin, Daniel, Janssen, Bert J.C., Lambris, John D., Gros, Piet
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713992/
https://www.ncbi.nlm.nih.gov/pubmed/19503104
http://dx.doi.org/10.1038/ni.1755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713992/
https://www.ncbi.nlm.nih.gov/pubmed/19503104
http://dx.doi.org/10.1038/ni.1755

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