Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines

BACKGROUND: The Hedgehog (HH) pathway promotes tumorigenesis in a diversity of cancers. Activation of the HH signaling pathway is caused by overexpression of HH ligands or mutations in the components of the HH/GLI1 cascade, which lead to increased transactivation of GLI transcription factors. Althou...

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Detalles Bibliográficos
Autores principales: Mizuarai, Shinji, Kawagishi, Aki, Kotani, Hidehito
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714036/
https://www.ncbi.nlm.nih.gov/pubmed/19575820
http://dx.doi.org/10.1186/1476-4598-8-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714036/
https://www.ncbi.nlm.nih.gov/pubmed/19575820
http://dx.doi.org/10.1186/1476-4598-8-44

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