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Cytokine-secreting follicular T cells shape the antibody repertoire
High-affinity antibodies are critical for host protection and underlie successful vaccines. Generation of such antibodies requires T cell-dependent help, which mediates germinal center (GC) reactions where mutation and selection of B cells occurs. Using an interleukin 4 (IL-4)-reporter system, we sh...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714053/ https://www.ncbi.nlm.nih.gov/pubmed/19252490 http://dx.doi.org/10.1038/ni.1715 |