Cargando…
Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
γ-Secretase activity is vital for the transmembrane cleavage of Notch receptors and the subsequent migration of their intracellular domains to the nucleus. Notch overexpression has been associated with breast, colon, cervical and prostate cancers. We tested the effect of three different γ-secretase...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714234/ https://www.ncbi.nlm.nih.gov/pubmed/19513078 http://dx.doi.org/10.1038/sj.bjc.6605034 |