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Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

γ-Secretase activity is vital for the transmembrane cleavage of Notch receptors and the subsequent migration of their intracellular domains to the nucleus. Notch overexpression has been associated with breast, colon, cervical and prostate cancers. We tested the effect of three different γ-secretase...

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Detalles Bibliográficos
Autores principales:	Rasul, S, Balasubramanian, R, Filipović, A, Slade, M J, Yagüe, E, Coombes, R C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714234/ https://www.ncbi.nlm.nih.gov/pubmed/19513078 http://dx.doi.org/10.1038/sj.bjc.6605034

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