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Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy – a case report

BACKGROUND: Membrane-bound heat shock protein 70 (Hsp70) serves as a tumor-specific recognition structure for Hsp70-peptide (TKD) plus IL-2 activated NK cells. A phase I clinical trial has shown that repeated re-infusions of ex vivo TKD/IL-2-activated, autologous leukapheresis product is safe. This...

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Detalles Bibliográficos
Autores principales: Milani, Valeria, Stangl, Stefan, Issels, Rolf, Gehrmann, Mathias, Wagner, Beate, Hube, Kathrin, Mayr, Doris, Hiddemann, Wolfgang, Molls, Michael, Multhoff, Gabriele
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714296/
https://www.ncbi.nlm.nih.gov/pubmed/19549307
http://dx.doi.org/10.1186/1479-5876-7-50