Characterization of Whole Blood Gene Expression Profiles as a Sequel to Globin mRNA Reduction in Patients with Sickle Cell Disease

Global transcriptome analysis of whole blood RNA using microarrays has been proven to be challenging due to the high abundance of globin transcripts that constitute 70% of whole blood mRNA. This is a particular problem in patients with sickle cell disease, secondary to the high abundance of globin-e...

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Detalles Bibliográficos
Autores principales: Raghavachari, Nalini, Xu, Xiuli, Munson, Peter J., Gladwin, Mark T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714456/
https://www.ncbi.nlm.nih.gov/pubmed/19649296
http://dx.doi.org/10.1371/journal.pone.0006484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714456/
https://www.ncbi.nlm.nih.gov/pubmed/19649296
http://dx.doi.org/10.1371/journal.pone.0006484

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