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No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS

BACKGROUND: In any animal model of human disease a positive control therapy that demonstrates efficacy in both the animal model and the human disease can validate the application of that animal model to the discovery of new therapeutics. Such a therapy has recently been reported by Fornai et al. usi...

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Detalles Bibliográficos
Autores principales: Gill, Alan, Kidd, Joshua, Vieira, Fernando, Thompson, Kenneth, Perrin, Steven
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714460/
https://www.ncbi.nlm.nih.gov/pubmed/19649300
http://dx.doi.org/10.1371/journal.pone.0006489