Decreased BRCA1 Confers Tamoxifen Resistance in Breast Cancer Cells by Altering Estrogen Receptor-Coregulator Interactions

The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30–40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen recept...

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Detalles Bibliográficos
Autores principales: Wen, Jie, Li, Rong, Lu, Yunzhe, Shupnik, Margaret A.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714665/
https://www.ncbi.nlm.nih.gov/pubmed/18997820
http://dx.doi.org/10.1038/onc.2008.405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714665/
https://www.ncbi.nlm.nih.gov/pubmed/18997820
http://dx.doi.org/10.1038/onc.2008.405

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