Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism

BACKGROUND: Lafora disease (LD) is a fatal autosomal recessive neurodegenerative disease. A hallmark of LD is cytoplasmic accumulation of insoluble glucans, called Lafora bodies (LBs). Mutations in the gene encoding the phosphatase laforin account for ~50% of LD cases, and this gene is conserved in...

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Detalles Bibliográficos
Autores principales: Gentry, Matthew S, Pace, Rachel M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714694/
https://www.ncbi.nlm.nih.gov/pubmed/19545434
http://dx.doi.org/10.1186/1471-2148-9-138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714694/
https://www.ncbi.nlm.nih.gov/pubmed/19545434
http://dx.doi.org/10.1186/1471-2148-9-138

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