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Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism
BACKGROUND: Lafora disease (LD) is a fatal autosomal recessive neurodegenerative disease. A hallmark of LD is cytoplasmic accumulation of insoluble glucans, called Lafora bodies (LBs). Mutations in the gene encoding the phosphatase laforin account for ~50% of LD cases, and this gene is conserved in...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714694/ https://www.ncbi.nlm.nih.gov/pubmed/19545434 http://dx.doi.org/10.1186/1471-2148-9-138 |