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Responding to chromosomal breakage during M-phase: insights from a cell-free system

DNA double strand breaks (DSBs) activate ATM and ATR dependent checkpoints that prevent the onset of mitosis. However, how cells react to DSBs occurring when they are already in mitosis is poorly understood. The Xenopus egg extract has been utilized to study cell cycle progression and DNA damage che...

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Detalles Bibliográficos
Autores principales: Smith, Eloise, Costanzo, Vincenzo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714845/
https://www.ncbi.nlm.nih.gov/pubmed/19602227
http://dx.doi.org/10.1186/1747-1028-4-15