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Responding to chromosomal breakage during M-phase: insights from a cell-free system
DNA double strand breaks (DSBs) activate ATM and ATR dependent checkpoints that prevent the onset of mitosis. However, how cells react to DSBs occurring when they are already in mitosis is poorly understood. The Xenopus egg extract has been utilized to study cell cycle progression and DNA damage che...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714845/ https://www.ncbi.nlm.nih.gov/pubmed/19602227 http://dx.doi.org/10.1186/1747-1028-4-15 |