A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

A tissue-specific transcriptional enhancer, Eμ, has been implicated in developmentally regulated recombination and transcription of the immunoglobulin heavy chain (IgH) gene locus. We demonstrate that deleting 220 nucleotides that constitute the core Eμ results in partially active locus, characteriz...

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Detalles Bibliográficos
Autores principales: Chakraborty, Tirtha, Perlot, Thomas, Subrahmanyam, Ramesh, Jani, Anant, Goff, Peter H., Zhang, Yu, Ivanova, Irina, Alt, Frederick W., Sen, Ranjan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715034/
https://www.ncbi.nlm.nih.gov/pubmed/19414554
http://dx.doi.org/10.1084/jem.20081621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715034/
https://www.ncbi.nlm.nih.gov/pubmed/19414554
http://dx.doi.org/10.1084/jem.20081621

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