OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

Expansion and recruitment of CD4(+) Foxp3(+) regulatory T (T reg) cells are mechanisms used by growing tumors to evade immune elimination. In addition to expansion of effector T cells, successful therapeutic interventions may require reduction of T reg cells within the tumor microenvironment. We rep...

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Detalles Bibliográficos
Autores principales: Hirschhorn-Cymerman, Daniel, Rizzuto, Gabrielle A., Merghoub, Taha, Cohen, Adam D., Avogadri, Francesca, Lesokhin, Alexander M., Weinberg, Andrew D., Wolchok, Jedd D., Houghton, Alan N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715041/
https://www.ncbi.nlm.nih.gov/pubmed/19414558
http://dx.doi.org/10.1084/jem.20082205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715041/
https://www.ncbi.nlm.nih.gov/pubmed/19414558
http://dx.doi.org/10.1084/jem.20082205

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