The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription

The activation-induced cytidine deaminase (AID) initiates somatic hypermutation, class-switch recombination, and gene conversion of immunoglobulin genes. In vitro, AID has been shown to target single-stranded DNA, relaxed double-stranded DNA, when transcribed, or supercoiled DNA. To simulate the in...

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Detalles Bibliográficos
Autores principales: Shen, Hong Ming, Poirier, Michael G., Allen, Michael J., North, Justin, Lal, Ratnesh, Widom, Jonathan, Storb, Ursula
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715043/
https://www.ncbi.nlm.nih.gov/pubmed/19380635
http://dx.doi.org/10.1084/jem.20082678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715043/
https://www.ncbi.nlm.nih.gov/pubmed/19380635
http://dx.doi.org/10.1084/jem.20082678

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