Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability

Artemis was initially discovered as the gene inactivated in human radiosensitive T(−)B(−) severe combined immunodeficiency, a syndrome characterized by the absence of B and T lymphocytes and cellular hypersensitivity to ionizing radiation. Hypomorphic Artemis alleles have also been identified in pat...

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Detalles Bibliográficos
Autores principales: Huang, Ying, Giblin, William, Kubec, Martina, Westfield, Gerwin, St. Charles, Jordan, Chadde, Laurel, Kraftson, Stephanie, Sekiguchi, JoAnn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715118/
https://www.ncbi.nlm.nih.gov/pubmed/19349461
http://dx.doi.org/10.1084/jem.20082396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715118/
https://www.ncbi.nlm.nih.gov/pubmed/19349461
http://dx.doi.org/10.1084/jem.20082396

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